Main Street Inn
404 S. Main St., Galena, IL 61036
Vacation Rentals
Located on Galena's historic downtown Main Street, the Main Street Inn is a cozy, inviting place to relax that is listed on the National Register of Historic Places (circa 1850).
Main Street Inn offers 6 luxurious and spacious rooms located on the 2nd floor that will meet the needs of romantic adventures, friend getaways, or anything in between. Walk out the front door to take a stroll up Main Street and browse through Galena's unique stores and boutiques, enjoy dining at one of Galena's fine restaurants, or stop by one of our wine shops. Or stay in and simply enjoy the comforts of your room.
Whatever your reason for coming to Galena, the Main Street Inn is here for you!
What's happening nearby...

Galena 5k Stair Challenge
Sep 13 @ 9AM
The Galena 5K Stair Challenge, hosted by The Galena Area EMS District, Galena Police Department, and Galena Fire Department, is an annual event honoring heroes of…
Read more about Galena 5k Stair Challenge
Galena Historical Society's 31st Annual Cemetery Walk
Greenwood Cemetery • Sep 13 – Sep 14 @ 1PM
Performers of the Cemetery Walk will be exploring the rugged lives of early settlers, sharing stories of prosperity and the challenges of intersecting cultures, politics, war and…
Read more about Galena Historical Society's 31st Annual Cemetery Walk
Galena Cellars Annual Fall Harvest Festival
Galena Cellars Vineyard & Winery • Sep 27 @ 11AM
Join Galena Cellars as they celebrate the 2025 Harvest! The 15th Annual Fall Harvest & Art Festival will take place at the Galena Cellars Vineyard.
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